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SUMMARY:Humoral immunity in the lung\; spatiotemporal regulation of reside
 nt memory B cell responses to infection with influenza virus - Dr Tal Arno
 n\; Kennedy Institute\, University of Oxford
DTSTART:20230209T133000Z
DTEND:20230209T143000Z
UID:TALK193666@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Dr Tal Arnon PhD is a Wellcome Trust Investigator and an assoc
 iate Professor at the Kennedy Institute in the University of Oxford. She o
 btained her PhD from The Hebrew University in Jerusalem and was trained as
  a postdoctoral Fellow with Professor Jason Cyster in UCSF. In 2014\, she 
 joined the University of Oxford to establish her own group. Her research f
 ocuses on understanding basic mechanisms that regulate lymphocyte traffick
 ing and B cell responses.\n\nIn recent years\, a previously unappreciated 
 subset of non-recirculating memory B cells have been shown to develop and 
 persist in the lungs of influenza infected hosts. To study the microanatom
 ical distribution of these cells in the lung and to explore mechanisms tha
 t activate them during rechallenge\, we developed mouse models and imaging
  procedures to directly trace resident memory B cells in situ\, in live lu
 ngs of influenza infected mice. Our study revealed that\, upon re-challeng
 e\, an alveolar macrophage orchestrated cascade of events leads to an accu
 mulation of resident memory B cells within sites of infection\, a process 
 that culminates in the differentiation of plasma cells in these regions. G
 iven that one plasma cell can secret thousands of antibodies per minute\, 
 this process may represent a powerful mechanism to efficiently block viral
  dissemination. \n
LOCATION:Kings Hedges Room 
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