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SUMMARY:Compartmentalised metabolism and metabolite signalling to the nucl
 eus - Dr Sophie Trefely\, Signalling and Epigenetics\, The Babraham Instit
 ute\, Cambridge
DTSTART:20230214T131500Z
DTEND:20230214T141500Z
UID:TALK194341@talks.cam.ac.uk
CONTACT:Angela Lumsdon
DESCRIPTION:Intracellular metabolites act as powerful signalling cues to a
 djust cell behaviour to the nutrient environment. A variety of metabolites
  operate in the nucleus as substrates\, co-factors\, or inhibitors of chro
 matin-modifying enzymes and have emerged as key determinants of gene regul
 ation. Given that cellular metabolism is highly compartmentalized\, our un
 derstanding of pathways connecting nutrients to nuclear metabolites has be
 en limited since standard metabolite analyses use whole cells. I will talk
  about my recent work on the development of novel approaches for sub-cellu
 lar metabolite analyses by mass spectrometry\, with a focus on the acyl-Co
 enzyme A metabolite class. This work shows that the nucleus operates as a 
 distinct metabolic compartment and marks an exciting step forward in under
 standing regulation of metabolism within the nucleus and how this links di
 et to the epigenome.\n\nTo receive information about this seminar series\,
  we would encourage you to join "Cambridge Metabolism":www.metabolism.cam.
 ac.uk.  Alternatively please contact aml95@medschl.cam.ac.uk for the Zoom 
 link
LOCATION:in person &amp\; via zoom 
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