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SUMMARY:The Wonders of Small Molecule Transport  - Professor David Drew | 
 Stockholm University 
DTSTART:20230215T150000Z
DTEND:20230215T160000Z
UID:TALK194428@talks.cam.ac.uk
CONTACT:Hannah Burns
DESCRIPTION:Solute Carrier (SLC) transporters mediate the translocation of
  substrates across membranes and after GPCRs represent the second-largest 
 fraction of the human membrane proteome. SLC transporters are critical to 
 cell homeostasis\, which is reflected in the fact that more than a quarter
  of them are associated with Mendelian disease. Despite a few exceptions\,
  however\, they have been under-utilized as drug targets and our mechanist
 ic understanding has been hampered due to technical difficulties in workin
 g with them. Here\, I will present our multidisciplinary approach that has
  revealed important insights into the mechanism of SLC2 (GLUT) and SLC9 (N
 a+/H+ exchanger) transporter families that are important for our cells to 
 utilize glucose as an energy source\, and for the regulation cytoplasmic a
 nd organellar pH. I will also present our most recent biochemical and stru
 ctural insights into ADP/ATP exchanger belonging to the SLC35 (nucleotide-
 sugar) family\, which is essential for the uptake of ATP into ER and Golgi
  organelles for a number of biological processes\, such as protein-folding
 .
LOCATION:MRC MBU\, Level 7 Lecture Theatre\, The Keith Peters Building\, C
 B2 0XY
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