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SUMMARY:Molecular Understanding\, Design and Development of Zwitterionic-b
 ased Biomaterials - Prof Shaoyi Jiang\, Boeing-Roundhill Professor of Chem
 ical Engineering &amp\;  Adjunct Professor of Bioengineering\, University 
 of Washington\, Seattle
DTSTART:20090826T130000Z
DTEND:20090826T140000Z
UID:TALK19448@talks.cam.ac.uk
CONTACT:Catherine Jordan
DESCRIPTION:An important challenge in many applications ranging from biome
 dical devices to ship hulls is the prevention of nonspecific biomolecular 
 and microorganism attachment on surfaces. For example\, nonspecific protei
 n adsorption degrades the performance of surface-based diagnostic devices 
 and causes an adverse effect on the healing process for implanted biomater
 ials. Our goals are to provide a fundamental understanding of molecular-le
 vel nonfouling mechanisms using an integrated experimental and simulation 
 approach and to develop biocompatible and environmentally benign ultra low
  fouling materials based on design principles. Over the last few years\, w
 e have demonstrated that zwitterionic and mixed charge materials and surfa
 ces are highly resistant to nonspecific protein adsorption from undiluted 
 blood plasma/serum and to bacterial adhesion/biofilm formation. In additio
 n to their excellent nonfouling properties\, zwitterionic carboxybetaine-b
 ased materials have abundant functional groups for ligand immobilization w
 hile cationic zwitterionic precursors have self-sterilizing capabilities. 
 Both simulation and experimental results show that the strong hydration of
  zwitterionic materials is responsible for their excellent nonfouling prop
 erties. At present\, zwitterionic materials have been applied to a number 
 of applications\, including implantable medical devices\, protein arrays\,
  targeted drug/gene delivery carriers\, antimicrobial coatings\, and marin
 e coatings.		
LOCATION:Unilever Lecture Theatre\, Department of Chemistry
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