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SUMMARY:Exploring cell heterogeneity in health and disease using single-ce
 ll proteomics and transcriptomics - Erwin Schoof\, Technical University of
  Denmark (DTU)
DTSTART:20231127T123000Z
DTEND:20231127T133000Z
UID:TALK194671@talks.cam.ac.uk
CONTACT:Ciara Adeniyi-Jones
DESCRIPTION:Single-cell proteomics by Mass Spectrometry (scp-MS) can provi
 de valuable insights into distinct cell-states and signalling patterns pre
 sent in a cell population. However\, carrying out proteomics profiling fro
 m the limited amount of material encapsulated in an individual cell presen
 ts significant challenges. Tremendous efforts have been made to optimize a
 ll aspects of scp-MS\, with the aim of minimizing losses during sample pre
 paration and maximizing sensitivity of data acquisition.\n \nHere\, we wil
 l present recent approaches developed in the Cell Diversity Lab. We will c
 over key aspects of the entire workflow\, and showcase the application of 
 our methods to biological questions spanning across stem cell differentiat
 ion. With a particular focus on the healthy and malignant human blood syst
 em\, we aim to convey possible biomedical implications of scp-MS\, and the
  joint assessment of transcriptomes and proteomes at the single-cell level
 . Through these examples\, we provide an overview of the current technolog
 ical state of the field\, and highlight key challenges that remain to be s
 olved.
LOCATION:CRUK CI Lecture Theatre
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