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SUMMARY:Immunity activation and execution in plants: a biochemical perspec
 tive - Professor Jane Parker\, Max Planck Institute\, Germany
DTSTART:20230518T111500Z
DTEND:20230518T124500Z
UID:TALK194722@talks.cam.ac.uk
CONTACT:Jake Harris
DESCRIPTION:For innate immunity\, seed plant species have evolved large fa
 milies of variable receptors to detect pathogen molecules and trigger dise
 ase resistance. Intracellular nucleotide-binding/leucine-rich-repeat (NLR)
  receptors are major determinants of resistance against host-adapted patho
 gens. Recent advances have been made in determining biochemical processes 
 underlying NLR activation by different pathogen molecules and how pathogen
 -specific recognition events then signal to resistance and cell death exec
 ution machineries. My group has been studying a large NLR receptor sub-cla
 ss in dicot plants called TIR-NLRs (TNLs) which have Toll-Interleukin1-rec
 eptor (TIR) enzymatic signalling domains. I’ll describe our current unde
 rstanding of TIR domain catalytic functions\, when embedded in NLRs but al
 so as TIR-only (non-NLR) proteins\, in generating nucleotide-based second 
 messengers for immunity. I’ll also consider emerging evidence of TIR cat
 alytic versatility in producing nucleotide-based stimulators and suppresso
 rs of host immune responses across kingdoms.
LOCATION:Online / Plant Sciences LLT for Department members only
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