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SUMMARY:The importance of vaccinated individuals to population-level evolu
 tion of pathogens - Maria A. Gutierrez - University of Cambridge
DTSTART:20230118T120000Z
DTEND:20230118T130000Z
UID:TALK194974@talks.cam.ac.uk
CONTACT:Paula Smith
DESCRIPTION:In this talk\, I will present the research of my PhD on vaccin
 e escape\, working with Julia Gog. Using compartmental SIR-style models wi
 th imperfect vaccination\, we allow for the probability of immune escape t
 o differ in vaccinated and unvaccinated hosts. As the relative contributio
 n to selection in these different hosts varies\, the overall effect of vac
 cination on the antigenic escape pressure at the population level changes.
  If vaccinated hosts do not contribute much more than unvaccinated hosts t
 o the escape pressure\, then increasing vaccination always reduces the ove
 rall escape pressure. In contrast\, if vaccinated hosts contribute signifi
 cantly more than unvaccinated hosts to the population level escape pressur
 e\, then the escape pressure is maximised for intermediate vaccination lev
 els.\nThis work is part of a recent preprint\, but I will also present fur
 ther extensions. Reinfections may also contribute differently to escape\, 
 and their presence changes the shape of the escape pressure as a function 
 of the vaccination coverage. We also extend our model to include populatio
 n heterogeneity. The presence of immunocompromised hosts\, who contribute 
 more to immune escape\, can lead to new overall patterns in the escape pre
 ssure. This work highlights the potential value of understanding better ho
 w the contribution to antigenic escape pressure depends on individual host
  immunity.\n
LOCATION:Zoom
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