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SUMMARY:To regenerate or not to regenerate? Recovering shape and function 
 in damaged jellyfish - Dr Chiara Sinigaglia (Observatoire Océanologique d
 e Banyuls-sur-Mer)
DTSTART:20230308T130000Z
DTEND:20230308T140000Z
UID:TALK195910@talks.cam.ac.uk
CONTACT:Christine Hirschberger
DESCRIPTION:How randomly injured animals can appropriately re-establish po
 sitional information and control the deployment of repair programs are key
  questions of regenerative biology. The small hydrozoan medusae _Clytia he
 misphaerica_\, which are frequently damaged in the plankton\, display powe
 rful regenerative capacities\, being able to regain a circular shape in le
 ss than 12 hours and a new functional mouth in 4 days. This efficient reco
 very depends on an interplay between mechanical forces\, cell migration an
 d proliferation\, which we are just starting to unravel. In particular\, w
 e showed that the umbrella remodeling causes the radial muscle fibers in t
 he subumbrellar layer to converge into ‘hubs’\, associated to activati
 on of Wnt signaling\, and which function as positional landmarks. The diff
 erent observed configurations of these muscle fibers correlate with a spec
 ific pattern of Wnt signaling activation\, and - most remarkably - with th
 e fate of the wound\, notably whether a mouth regenerative program will be
  activated. In a second phase\, mouth morphogenesis is fueled by both loca
 l cell proliferation and long-range cell recruitment and is further modula
 ted by its connections with the gastrovascular canal system.\nClytia medus
 ae offer a novel experimental paradigm for addressing patterning formation
  and morphogenesis in tractable adult bodies\, dissecting the interplay be
 tween chemical and mechanical cues in pattern formation. Finally\, the div
 ersity of repair strategies observed across cnidarians species provides a 
 key opportunity to start unraveling the evolution of regenerative capaciti
 es.
LOCATION:Part II Lecture Theatre\, Department of Zoology
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