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SUMMARY:Cephalo-pelvic integration in hybrid mouse models and implications
  for human obstructed labour  - Eva Zaffarini (McCaig Institute\, Universi
 ty of Calgary)
DTSTART:20230213T143000Z
DTEND:20230213T153000Z
UID:TALK195982@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:The extremely tight fit between fetal head and maternal pelvic
  canal during childbirth is a cause of high mortality in humans. However\,
  the relatively narrow size of the female pelvis\, evolved for efficient b
 ipedal locomotion\, shows morphological covariation with head size\, a hig
 hly heritable trait. This covariation is thought to reduce the risk of cep
 halo-pelvic mismatch and obstructed labour1. Morphological covariation ari
 ses through the evolution of mechanisms that mediate the coordinated devel
 opment of functionally related characters2. Hybridization often reduces th
 e degree of morphological integration between characters via genetic intro
 gression3. My research investigates how hybridization in mice influences m
 orphological covariation between skull and pelvis in relation to obstructe
 d labour. After quantifying skull and pelvic shape in different wild mice 
 species and their hybrids\, I test the change in their degree and patterns
  of shape covariation\, especially focusing on obstetric-relevant aspects 
 of the pelvis and skull. 
LOCATION:Online
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