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SUMMARY:Life and death of cells a mystery solved through biomechanics  - L
 akshmi Balasubramaniam (Gurdon Institute\, University of Cambridge) 
DTSTART:20230306T143000Z
DTEND:20230306T153000Z
UID:TALK195991@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:Tissue homeostasis of matured epithelia are maintained through
  a tight balance of cell proliferation and cell extrusion. The fate of the
  extruding cell and its viability plays a major role in determining health
  of the tissue. In this work we show that removal of E-cadherin an adheren
 s junction protein leads to an increase in live cell extrusion. This live 
 cell extrusion is accompanied by a switch in the direction of cell extrusi
 on from apical to basal side. Mechanical measurements combined with phase 
 field modelling show that local stress fluctuations regulate the mode of e
 xtrusions due to changes in cell-cell adhesions and internal activity. Thi
 s form of live and basal extrusion can be a mode of cell extravasation dur
 ing cancer. 
LOCATION:Online
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