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SUMMARY:Nanoplasmonic analysis of extracellular vesicles for cancer diagno
 stics - Professor Randy Carney\, Dept. of Biomedical Engineering\, Univers
 ity of California\, Davis\, USA.
DTSTART:20230126T150000Z
DTEND:20230126T160000Z
UID:TALK196483@talks.cam.ac.uk
CONTACT:112876
DESCRIPTION:Cancer pathology is dramatically mediated by a number of key p
 roteins\, lipids\, small molecules\, and nucleic acids trafficked in exoso
 mes and related nanoscale extracellular vesicles (EVs). Sensitive and spec
 ific detection of the cell-specific biomaterials recruited and packaged in
  EVs has the potential to improve identification and monitoring of cancer\
 , particularly for those types lacking early screening. Yet current method
 s for phenotyping EVs released into blood circulation cannot easily nor ra
 pidly distinguish tumor-associated from non-tumor associated particles. \n
 \nThis talk introduces our lab’s Raman spectroscopy platform to molecula
 rly characterize EVs and quantitatively assess chemical composition at sin
 gle particle resolution. We show that tumor-released EVs can be readily di
 stinguished from healthy ones using label-free spectroscopy analysis. By e
 xtending to surface-enhanced Raman scattering (SERS) via nanoscale metal s
 ubstrates and particles\, we can achieve rapid\, sensitive detection of tu
 mor EVs in patient biofluids\, which has recently opened up new insights t
 o the importance of the EVs’ glycocalyx coating for improved diagnostic 
 specificity. \n\n
LOCATION:Goldsmith's 2 &amp\; https://us06web.zoom.us/j/81688365420?pwd=b3
 RpdHgxNVhWbWQrbXluMUxYNWVtQT09 Meeting ID: 816 8836 5420 Passcode: 047859
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