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SUMMARY:Phenotypic heterogeneity in bacterial stress response - Stephan Up
 hoff (Department of Biochemistry\, University of Oxford)
DTSTART:20230222T113000Z
DTEND:20230222T123000Z
UID:TALK196765@talks.cam.ac.uk
CONTACT:Margarida Rodrigues
DESCRIPTION:Genetically-identical bacterial cells commonly display differe
 nt phenotypes\, especially in response to environmental stress. What cause
 s phenotypic heterogeneity and how does it affect adaptation of bacterial 
 populations during stress? We address these questions using a combination 
 of single-molecule imaging\, single-cell analysis via microfluidics\, mach
 ine-learning\, and quantitative modelling. We currently focus on three maj
 or stress responses in E. coli bacteria\; the adaptive response to alkylat
 ion stress\, the SOS response to DNA damage\, and the oxidative stress res
 ponse. We observe substantial phenotypic heterogeneity for each type of re
 sponse\, but uncover that the underlying mechanisms are fundamentally diff
 erent and have unexpected consequences for the behaviour of the cell popul
 ation under stress.
LOCATION:James Dyson Building Seminar Room - Department of Engineering
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