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SUMMARY:Strong CH Hydrogen Bonds: The Newest Player in the field of Anion 
 Receptors - Professor Amar Flood\, University of Indiana
DTSTART:20100225T140000Z
DTEND:20100225T153000Z
UID:TALK19704@talks.cam.ac.uk
CONTACT:Sian Bunnage
DESCRIPTION:Anions are everywhere. The binding and transport of them are p
 rocesses carried out an infinite number of times inside cells every day. D
 eficiencies in these processes can cause health problems. Therefore\, sens
 ing and manipulating anions using supramolecular chemistry is one way to i
 nvestigate these links to our wellbeing. As this field continues to grow\,
  philosophies behind receptor design are being re-evaluated through theory
  and experiment. Here we consider the anion binding potential of activated
  CH hydrogen bond donors\, rivaling that of traditional NH donors\, using 
 macrocyclic receptors called triazolophanes. These receptors show surprisi
 ngly strong anion affinities wherein CH hydrogen bond donors act as the so
 le source of anion stabilization. Quantitative inspection of the facts rev
 eals that CH donors from click-chemistry installed 1\,2\,3-triazoles are e
 xtrinsically activated. Thus\, we offer a broadened concept of what a “s
 trong” hydrogen bond donor is for the design of anion receptors. 
LOCATION:Unilever Lecture Theatre\, Department of Chemistry
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