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SUMMARY:Seminar - Diabetes No More: lessons from the DiRECT trial and beyo
 nd - Professor Mike Lean - Professor Mike Lean\, University of Glasgow
DTSTART:20230220T130000Z
DTEND:20230220T140000Z
UID:TALK197071@talks.cam.ac.uk
CONTACT:Paul Browne
DESCRIPTION:This hybrid seminar will be held in the meeting rooms\, Level 
 4\, Wellcome-MRC Institute of Metabolic Science\, Addenbrooke’s Hospital
 \, Cambridge\, CB2 0QQ\, and online.\n\nFree registration to attend this s
 eminar in person at:\n\nhttps://www.eventbrite.com/e/diabetes-no-more-less
 ons-from-the-direct-trial-and-beyond-prof-mike-lean-tickets-536094692657\n
 \nFree registration to join this seminar online at:\n\nhttps://mrc-epid.zo
 om.us/meeting/register/tJIrduqsrD0tH9FccP1uJ-Rzmk1bRy7JyCl8\n\nAfter regis
 tering\, you will receive a confirmation email containing information abou
 t joining the meeting.\n\nAbout this talk\nThree RCT trials\, conducted en
 tirely in primary care using low-calorie formula diets for 8-12 weeks\, ha
 ve reported remissions for 40-60% of participants including South Asians\,
  and 70-80% with weight loss >10kg\, well maintained at 2 years. Hypertens
 ion and NAFLD\, commonly accompanying T2D\, normalized for ~30%. Remission
  was accompanied by normalization of ectopic fat in liver and pancreas\, a
 nd insulin production capacity. With fewer serious adverse events\, total 
 medical care costs fell and cost-effectiveness analysis projected people t
 o live longer\, feel better and cost less. Remissions are strongly driven 
 by weight loss\, but new methods are needed to support longer maintenance.
LOCATION:MRL meeting rooms 1 &amp\; 2\, Level 4 Institute of Metabolic Sci
 ences\, Addenbrooke’s Treatment Centre (ATC) 
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