BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Microbial growth behavior and the control of protein synthesis in 
 and out of steady state - Jonas Cremer\, Stanford University
DTSTART:20230216T140000Z
DTEND:20230216T150000Z
UID:TALK197236@talks.cam.ac.uk
CONTACT:Fulvio Forni
DESCRIPTION:Fast growth is central for microbial life and microbes thus ne
 ed to finetune their cell machinery for rapid biomass accumulation. In thi
 s talk I discuss recent advances in understanding this coordination for th
 e model organism Escherichia coli. Via the lens of a low-dimensional theor
 y I particularly consider how growth is shaped by a balance between protei
 n synthesis (via ribosomes) and the metabolic processes which are needed t
 o sustain ribosomal activity. An extensive comparison with data establishe
 s the mathematical framework and shows how cells adjust the balance betwee
 n metabolism and ribosome activity to navigate the constraints of protein 
 synthesis in steady conditions. Mechanistically this balance is accomplish
 ed by a control circuit in which the molecule guanosine pentaphosphate ser
 ves as a central regulator which senses the availability of metabolites an
 d controls the synthesis of metabolic and ribosomal proteins. I discuss th
 e functioning of this circuit and how its mathematical implementation allo
 ws to predict cellular growth even beyond steady growth and when condition
 s rapidly change.\n\nThe seminar will be held in the JDB Seminar Room\, De
 partment of Engineering\, and online (zoom): https://us06web.zoom.us/j/879
 86687566?pwd=MGJScmMwd2lwT0tVMHNmWmxSa05XZz09
LOCATION:Department of Engineering / Online (Zoom)
END:VEVENT
END:VCALENDAR