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SUMMARY:Design principles of complex cellular decision-making networks dur
 ing cancer metastasis - Mohit Kumar Jolly\, IISc Bangalore
DTSTART:20230302T140000Z
DTEND:20230302T150000Z
UID:TALK197884@talks.cam.ac.uk
CONTACT:Fulvio Forni
DESCRIPTION:Elucidating the principles of cellular decision-making is of f
 undamental importance. These decisions are often orchestrated by underlyin
 g regulatory networks. While we understand the dynamics of simple network 
 motifs\, how large networks lead to a limited number of phenotypes\, despi
 te their complexity\, remains largely elusive. Here\, we investigated mult
 iple different networks governing cellular plasticity engaged in cancer me
 tastasis and identified a latent design principle in their topology that l
 imits their phenotypic repertoire – the presence of two “teams” of n
 odes engaging in a mutually inhibitory feedback loop\, forming a toggle sw
 itch. These "teams" are specific to these networks and directly shape the 
 phenotypic landscape and consequently the frequency and stability of termi
 nal phenotypes vs. the intermediary ones. Our analysis reveals that networ
 k topology alone can contain information about phenotypic distributions it
  can lead to\, thus obviating the need to simulate them. We present experi
 mental evidence of such "teams" in transcriptomic datasets across many con
 texts and unravel topological signatures that can drive canalization of ce
 ll-fates during decision-making processes.\n\nThe seminar will be held in 
 the JDB Seminar Room\, Department of Engineering\, and online (zoom): http
 s://us06web.zoom.us/j/87986687566?pwd=MGJScmMwd2lwT0tVMHNmWmxSa05XZz09
LOCATION:Department of Engineering / Online (Zoom)
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