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SUMMARY:Mechanisms that Contribute to Proteostasis Collapse in Aging and D
 isease - Prof Richard I. Morimoto\, Department of Molecular Biosciences\, 
 Rice Institute of Biomedical Research\, Northwestern University\, USA
DTSTART:20230309T111500Z
DTEND:20230309T121500Z
UID:TALK197980@talks.cam.ac.uk
CONTACT:Alyssa Miller
DESCRIPTION:Proteostasis and the regulation of cellular protein quality co
 ntrol mechanisms are essential for the stability and function of the entir
 e proteome and cellular health and organismal lifespan. Consequently\, pro
 teostasis collapse in aging represents an initiating programmed event in b
 iology that promotes protein misfolding\, mislocalization\, aggregation of
  proteins. In turn\, these events interfere with the stability\, compositi
 on and stoichiometry of the proteome leading to amplification of dysregula
 ted cellular processes. We employ genetic\, biochemical and proteomic meth
 ods to understand how proteome stability is achieved\, to establish the mo
 lecular basis of proteostasis collapse and to understand the underlying co
 mplexity and magnitude of proteome instability in stress\, aging and disea
 se.
LOCATION:Department of Chemistry\, Unilever Lecture Theatre
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