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SUMMARY:Biological energy transduction in action - deciphering the molecul
 ar mechanism of the remarkable Complex I - Professor Ville Kaila | Stockho
 lm University
DTSTART:20231101T150000Z
DTEND:20231101T160000Z
UID:TALK198187@talks.cam.ac.uk
CONTACT:Lisa Arnold
DESCRIPTION:Complex I is a gigantic membrane-bound enzyme that transduces 
 redox energy into a proton motive force across a biological membrane\, pow
 ering cellular respiration. Despite major advances in recent years\, its e
 nergy transduction principle remains unsolved and a major challenge. In th
 is talk\, I describe our integrative biophysical\, computational\, and str
 uctural approach to derive a molecular understanding of the long-range pro
 ton-pumping principles within the Complex I superfamily. Our findings reve
 al how the substrate reduction triggers conformational and hydration chang
 es\, how the protonation signal propagates across the membrane domain of t
 he complex\, and how engineering the elementary building blocks allows us 
 to identify key mechanistic principles and probe effects underlying diseas
 e-related mutations. We suggest that Complex I employs electric field effe
 cts to control both catalysis and ion-transport\, with striking physical s
 imilarities to other enzymes.
LOCATION:MRC MBU\, Level 7 Lecture Theatre\, The Keith Peters Building\, C
 B2 0XY
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