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SUMMARY:Regulation of DNA repair by monoubiquitin signals - Professor Hele
 n Walden\; University of Glasgow
DTSTART:20230330T100000Z
DTEND:20230330T110000Z
UID:TALK198193@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:The Fanconi Anemia DNA repair pathway is needed to fix DNA int
 erstrand crosslinks. At the heart of the pathway is a single monoubiquitin
  signal which is attached to two homologous proteins\, FANCD2 and FANCI. B
 oth the assembly and the removal of the signal are required for completion
  of interstrand crosslink repair. My lab focusses on understanding the mec
 hanisms of assembly\, functional consequence\, and removal of specific ubi
 quitin signals. I will present our biochemical and structural data definin
 g each of these steps\, from how a single site is targeted for modificatio
 n\, what the addition of ubiquitin does to the ID2 complex\, how each ubiq
 uitin signal has a distinct function\, and how the signal is removed from 
 a specific site.
LOCATION:Queen Edith's Room\; Babraham Research Campus
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