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SUMMARY:Correlative imaging to resolve molecular structures in living tiss
 ues - Dr. Oxana Klementieva\, Associate professor in molecular imaging\, D
 epartment of Experimental Medicine\, Lund University\, Sweden
DTSTART:20230322T103000Z
DTEND:20230322T113000Z
UID:TALK198523@talks.cam.ac.uk
CONTACT:Alyssa Miller
DESCRIPTION:Label-free chemical imaging of complex living systems is the h
 oly grail of biochemical research. The current analysis techniques require
  extensive sample preparation\, often due to the presence of interfering m
 olecules such as water\, making them unsuitable for the analysis of such s
 ystems. Here\, we examined living tissues and small vertebrates at sub-mic
 ron resolution by optical photothermal infrared microspectroscopy.  In my 
 talk I will address recent advances of infrared spectroscopy and explain h
 ow it can be used to analyze at submicron resolution fresh\, unprocessed\,
  fully hydrated tissue biopsies from diverse organs including brain\, to y
 ield structural and compositional insights into spatiotemporal changes wit
 h relevance to diseases. I will also show that now infrared information ca
 n be extracted from living organisms\, such as salamander embryos\, withou
 t compromising development. Thus\, demonstrating time-resolved and in situ
  investigation of chemical and structural changes of diverse biomolecules 
 in their native conditions. 
LOCATION:Department of Chemistry\, Unilever Lecture Theatre
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