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SUMMARY:Mapping metazoan gene regulatory networks to understand transcript
 ion factor function in health and disease - Bart Deplancke\,  Institute of
  Bio-engineering\, School of Life Sciences\,  Swiss Federal Institute of T
 echnology in Lausanne (EPFL)
DTSTART:20090929T093000Z
DTEND:20090929T113000Z
UID:TALK19895@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Differential gene expression is central to most fundamental bi
 ological processes\, but little is still known about the composition and d
 ynamic properties of the corresponding gene regulatory networks (GRNs) tha
 t control the expression of these genes. This is because we have yet much 
 to learn about the role of the majority of metazoan transcription factors\
 , which are the core members of these regulatory networks. The latter site
 -specific DNA-binding proteins function by integrating extra- and intracel
 lular cues through protein-protein or protein-ligand interactions and tran
 slating these cues into gene expression output by binding to gene regulato
 ry elements. Thus\, to generate comprehensive GRN models\, we aim to map a
 ll regulatory TF-DNA and higher-order TF-protein interactions and elucidat
 e their respective dynamic properties. Here\, I will present the latest ef
 forts of our lab to develop and apply novel resources and both experimenta
 l and bioinformatic tools to achieve a quantitative understanding of the r
 egulatory mechanisms that control metazoan gene expression. 
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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