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SUMMARY:Curbing mitochondrial dysfunction in neurodegeneration: lessons fr
 om neurogenetics - Dr Derek Narendra | National Institute of Neurological 
 Disorders and Stroke
DTSTART:20230425T140000Z
DTEND:20230425T150000Z
UID:TALK199234@talks.cam.ac.uk
CONTACT:Hannah Burns
DESCRIPTION:Among the causes of neurodegeneration are damaged mitochondria
  that accumulate with age\, particularly in post-mitotic neurons and myocy
 tes. Our group studies monogenic disorders to uncover mitochondrial stress
  responses that curb mitochondrial damage in neurodegeneration. Our focus 
 includes PINK1 and Parkin\, which form a stress-induced mitophagy pathway 
 that targets damaged mitochondria for degradation. Mutations in these gene
 s are the most common recessive forms of Parkinson’s disease\, linking m
 itophagy to neurodegeneration. We are additionally focused on dominant mut
 ations in the paralogs CHCHD2 and CHCHD10\, which cause Parkinson’s dise
 ase\, amyotrophic lateral sclerosis\, frontotemporal dementia\, and myopat
 hy. In addition to enabling precision therapies for these neurogenetic dis
 orders\, our work is uncovering fundamental mitochondrial stress responses
  to mitochondrial damage.
LOCATION:MRC MBU\, Level 7 Lecture Theatre\, The Keith Peters Building\, C
 B2 0XY
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