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SUMMARY:Selective autophagy as a mechanism of oxidative stress response - 
 Dr Viktor Korolchuk | Faculty of Medical Sciences\, Newcastle University
DTSTART:20231004T140000Z
DTEND:20231004T150000Z
UID:TALK199237@talks.cam.ac.uk
CONTACT:Lisa Arnold
DESCRIPTION:The talk will summarise several ongoing research projects in t
 he lab\, primarily focussing on autophagic degradation of mitochondria by 
 autophagy. We show that this homeostatic process\, termed mitophagy\, is e
 ssential for multiple aspects of cellular physiology. Mechanisms allowing 
 autophagy machinery to detect damaged mitochondria producing elevated leve
 ls of reactive oxygen species will be discussed. Likewise\, the talk will 
 illustrate some mechanistic links between autophagy dysfunction and the lo
 ss of cellular function leading to cell death or senescence. Based on our 
 data\, we propose that autophagy\, and specifically mitophagy\, are promis
 ing targets for interventions aiming to prevent age-related dysfunction an
 d diseases associated with ageing.
LOCATION:MRC MBU\, Level 7 Lecture Theatre\, The Keith Peters Building\, C
 B2 0XY
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