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SUMMARY:How do autophagosomes form and grow? - Dr Alex van Vliet\; MRC LMB
DTSTART:20230505T120000Z
DTEND:20230505T130000Z
UID:TALK199306@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Autophagy is vital for maintaining cellular homeostasis throug
 h the degradation of cellular components via the formation of double-membr
 aned autophagosomes. However\, the origin and growth of the autophagosome 
 membrane remain elusive. In this talk\, I will examine how the lipid \ntra
 fficking ATG9A-ATG2A complex sits at the heart of autophagosome formation\
 , and the impact of newly characterized protein complexes on autophagy and
  mitophagy.\n\nAlex completed his PhD at KU Leuven under Patrizia Agostini
 s\, \nsupported by an IWT scholarship\, working on how the ER stress kinas
 e PERK affects membrane contact sites. He then joined Sharon Tooze's lab a
 t the Francis Crick Institute as an EMBO fellow\, investigating the lipid 
 scramblase ATG9A's role in autophagosome biogenesis and characterizing the
  lipid trafficking ATG9A-ATG2A protein complex. He is currently researchin
 g Rab1's role in autophagy at the MRC LMB with Sean \nMunro.\n
LOCATION:Kings Hedges Room\, Babraham Research Campus
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