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SUMMARY:A journey through parasite genetics in search of protective antige
 ns - Dr Adrian Smith\, Dept of Zoology\, University of Oxford
DTSTART:20091007T113000Z
DTEND:20091007T123000Z
UID:TALK19933@talks.cam.ac.uk
CONTACT:Prof. Jim Kaufman
DESCRIPTION:Dr Adrian Smith Research Interests\n\nMy research is focussed 
 on understanding the basis of immunity to infectious challenge and include
 s studies of immune mechanisms that operate in different vertebrate specie
 s (particularly birds and mammals). I have a special interest in the mecha
 nisms of immunity in the gut and how different subsets of T lymphocytes co
 ntribute to protective immunity. Many responses are stimulated during infe
 ction but it is clear that only a subset of the response is involved in pr
 otective immunity. A central theme of the work of my group is directed tow
 ards defining which of the induced responses and cellular interactions are
  effective in pathogen control.\n\nCurrent projects include the comparativ
 e biology of pattern recognition receptors\, TCRαβ and TCRγδ T cell bi
 ology\, parasite genetics as a tool to define protective antigen-encoding 
 loci and the mechanisms of immunity against infection. Currently our focus
  is on immunity to parasitic protozoa (e.g. Eimeria spp) and bacterial (e.
 g. Salmonella enterica) pathogens. The knowledge gained in these studies c
 ontributes to our understanding of the basic biology of immune systems\, p
 rovides an integrated view of host-pathogen interactions and contributes t
 owards development of effective immune interventions (e.g. vaccines).\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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