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SUMMARY:HIV microbicides: current and emerging candidates - Professor Char
 les Kelly\, Oral Immunology\, King's College\, London
DTSTART:20091202T123000Z
DTEND:20091202T133000Z
UID:TALK19940@talks.cam.ac.uk
CONTACT:Prof. Jim Kaufman
DESCRIPTION:My main research interest is early events in infection at muco
 sal surfaces and particularly microbial attachment to host receptors with 
 the aim of developing approaches to prevent infection. Having previously w
 orked on Streptococcus mutans and Helicobacter pylori\, my focus now is th
 e development of compounds (microbicides) which can be applied topically t
 o prevent infection with HIV-1. For the last 6 years\, I have been coordin
 ating a project (European Microbicides Project\, EMPRO) with 25 partner in
 stitutions funded by the European Commission to develop novel microbicides
 . These include both HIV-1 entry-inhibitors such (e.g. single-domain antib
 odies\, RANTES analogues and CD4 mimetics) as well as small molecule inhib
 itors of events post HIV entry. I will present some of the findings from t
 his project including data from in vivo efficacy studies as well more deta
 iled analyses of DC-SIGN enhancement of HIV-1 entry.
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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