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SUMMARY:Synthetic ex utero embryogenesis:  from naive pluripotent stem cel
 ls to human and mouse bona fide embryo-models - Professor Jacob Hanna\, We
 izmann Institute\, Israel
DTSTART:20230627T100000Z
DTEND:20230627T110000Z
UID:TALK199663@talks.cam.ac.uk
CONTACT:Lynn Froggett
DESCRIPTION:The identity of somatic and pluripotent cells can be epigeneti
 cally reprogrammed and forced to adapt a new functional cell state by diff
 erent methods and distinct combinations of exogenous factors. The aspirati
 on to utilize such in vitro reprogrammed pluripotent and somatic cells for
  therapeutic purposes necessitates understanding of the mechanisms of repr
 ogramming and differentiation and elucidating the extent of equivalence of
  the in vitro derived cells to their in vivo counterparts. In my presentat
 ion\, I will present my group’s recent advances toward understanding the
 se fundamental questions and further detail our ongoing efforts to generat
 e developmentally unrestricted human naive pluripotent cells with embryoni
 c and extra- embryonic developmental potential. I will expand on new avenu
 es for utilizing custom made electronically controlled ex utero platforms 
 and optimized conditions for growing natural mammalian embryos ex utero fo
 r extended periods capturing development from pre-gastrulation until advan
 ced organogenesis\, for better studying of stem cell transitions during em
 bryogenesis and organogenesis. I will detail how the latter platforms offe
 red an exclusive technical platform to demonstrate and unleash the self-or
 ganizing capacity of mouse naïve PSCs to generate post- gastrulation synt
 hetic Bona Fide and organ-filled\, synthetic embryo models with both embry
 onic and extraembryonic compartment ex utero\, as well as our ability to e
 xtend these findings with human PSCs. Collectively\, I will be highlightin
 g prospects for new platforms for advancing human disease and developmenta
 l modelling.
LOCATION:Jean Thomas Lecture theatre\, Sanger Building\, Tennis Court Road
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