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SUMMARY:LMB Seminar: Power to the protein: analyse\, signal and protect wi
 th bacterial superglues - Professor Mark Howarth\, University of Cambridge
DTSTART:20231204T110000Z
DTEND:20231204T120000Z
UID:TALK199747@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:A special feature of the bacterium Streptococcus pyogenes enab
 les spontaneous amide bond formation within its surface proteins. We re-en
 gineered this system to generate an irreversible peptide-protein interacti
 on (SpyTag/SpyCatcher). This reaction is genetically-encodable\, specific 
 in diverse biological environments\, and occurs at a rate close to the dif
 fusion limit. Latest advances include a toolbox of modules for rapidly con
 trolling protein architectures and interaction switchable by temperature\,
  pH or light. We have also developed another bacterial superglue called Ne
 issLock for covalent reaction to endogenous human proteins via an anhydrid
 e. For targeting in the GI tract\, we have been engineering plant-based pr
 oteins with extreme resilience to low pH and proteases. Applications of th
 e technologies will be discussed for hydrogen-deuterium exchange\, cell th
 erapy and vaccination\, including for emerging pandemic threats.\n\nX/Twit
 ter account - @HowarthSci
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) and via Zoo
 m\, link: https://mrc-lmb-cam-ac-uk.zoom.us/j/95625236862?pwd=NGttT1d6ay9S
 WFRqUHMvRWNPdDhyZz09
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