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SUMMARY: Self-organisation of proteins: from collective phenomena to funct
 ion - Erwin Frey (LMU Munich)
DTSTART:20230509T120000Z
DTEND:20230509T130000Z
UID:TALK199939@talks.cam.ac.uk
CONTACT:Sarah Loos
DESCRIPTION:The spatial organisation of proteins is essential for many int
 racellular and cellular processes. Intracellular protein patterns organise
  cell division\, cell polarity\, and bud-site selection. Condensates of pr
 oteins that form on the nucleoid of bacterial cells exhibit self-propulsio
 n and move robustly toward the cell midplane\, controlling cell division. 
 Arrays of protein filaments and molecular motors assemble into micellar an
 d foam-like structures. Finally\, proteins self-assemble into information-
 rich aggregates ranging from filaments to complex molecular machines. All 
 these processes have in common that they are driven far from thermal equil
 ibrium by NTPase cycles\, chemical reaction cycles that break detailed bal
 ance. In this talk\, I will report on recent advances in our understanding
  of these active non-equilibrium processes\, focusing on how biochemical a
 nd geometric factors regulate them. In addition\, I will show that the fie
 lds of `active matter' and `protein pattern formation' are closely related
 \, both phenomenologically and in terms of their theoretical principles. A
 s an outlook\, I will discuss how a deeper understanding of the underlying
  physical principles might help guide the design of artificial systems wit
 h life-like functions.
LOCATION:Center for Mathematical Sciences\, Lecture room MR4
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