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SUMMARY:Modelling active morphogenesis of patterned epithelia  -  Diana Kh
 oromskaia (Crick Institute\, London)
DTSTART:20230424T133000Z
DTEND:20230424T143000Z
UID:TALK199969@talks.cam.ac.uk
CONTACT:Dr. Wolfram Pönisch
DESCRIPTION:Shape transformations of epithelial tissues in three dimension
 s are crucial for embryonic development and in vitro organoid growth and c
 an result from active forces generated within the cytoskeleton of the epit
 helial cells. How the interplay of local differential tensions with tissue
  geometry results in tissue-scale morphogenesis remains an open question. 
 \n\nWe present a model of epithelial sheets as active viscoelastic surface
 s and study their deformation under patterned internal tensions and bendin
 g moments. In addition to isotropic effects\, we take into account nematic
  alignment in the plane of the tissue\, which gives rise to shape-dependen
 t\, anisotropic active tensions and bending moments. We present phase diag
 rams of the mechanical equilibrium shapes of pre-patterned closed shells a
 nd explore their dynamical deformations. Our results show that a combinati
 on of nematic alignment and gradients in internal tensions and bending mom
 ents is sufficient to reproduce basic building blocks of epithelial morpho
 genesis\, including fold formation\, budding\, neck formation\, flattening
 \, and tubulation.  
LOCATION:Online
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