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SUMMARY:You shall not pass! How ectoderm patterning modulates lateral mese
 ndoderm migration in the early zebrafish gastrula. - Stefania Tavano\, IST
 A Vienna\, Austria 
DTSTART:20230515T133000Z
DTEND:20230515T143000Z
UID:TALK200053@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:Cell migration is a fundamental process in shaping organs and 
 organisms. However\, most of our knowledge in multicellular organisms rega
 rds extracellular matrix (ECM)-driven migration\, whereas much less is kno
 wn about how ECM-independent migration is regulated in vivo. To address th
 is\, we studied lateral mesendoderm (LME) migration in the early zebrafish
  gastrula\, as it occurs without ECM. Our data show that LME cells use the
  ectoderm rather than the yolk cell membrane as the primary substrate whil
 e undergoing animally-directed movement. Additionally\, we found that ecto
 derm is a pattern substate as lateral but not animal ectoderm is permissiv
 e to LME animal migration. Moreover\, the permissiveness of the ectoderm i
 s controlled by its tissue properties\, as the lateral ectoderm is more ri
 gid than the animal ectoderm. Indeed\, tuning ectodermal contractility via
  the actin cytoskeleton is sufficient to reverse the migration patterns in
  response to lateral and animal ectoderm. Finally\, BMP signalling is crit
 ical for delineating the nonpermissive animal ectoderm and inhibiting migr
 ation towards the animal pole. Our work points to the role of ectoderm pat
 terning in directly modulating LME animally-directed migration. Furthermor
 e\, it suggests that the modulatory activity of the ectoderm is establishe
 d by BMP signalling and relies on the material properties of the ectoderm 
 tissue.
LOCATION:Online
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