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SUMMARY:Tumor cell metastasis: Modeling the long and treacherous journey i
 n the circulation and escape at the metastatic site - Roger D Kamm\, MIT
DTSTART:20230602T150000Z
DTEND:20230602T160000Z
UID:TALK200755@talks.cam.ac.uk
CONTACT:Prof. Jerome Neufeld
DESCRIPTION:More than 90% of the mortality due to cancer is attributable t
 o metastatic disease\, yet we have at best a limited understanding of the 
 barriers faced by a tumor cell as it is convected by blood flow from the p
 rimary tumor to the remote metastatic site.  Our group has focused on deve
 loping physical models that address many of these barriers including: 1) a
 rrest in the remote microcirculation either by adhesion or trapping\, 2) s
 urvival while still inside the vessel against the stresses of fluid flow a
 nd immune cell attack\, 3) transmigration across the endothelial monolayer
 \, the stresses experienced by the tumor cell and the respective roles of 
 tumor cell adhesion and endothelial permissiveness or resistance to invasi
 on. In this presentation I will track the steps of the metastatic cascade 
 and demonstrate how physical and computational models can shed light on th
 ese rate limiting processes.\n\nwebinar link: https://cassyni.com/s/fmws
LOCATION:MR2 (also broadcast as JFM webinar)
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