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SUMMARY:Activation-induced proteome re-modelling in B cells and the role o
 f mTORC1 - Dr Andy Howden\; University of Dundee
DTSTART:20230620T123000Z
DTEND:20230620T133000Z
UID:TALK200758@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:In this talk I will summarise my recent work mapping the activ
 ated B cell proteome. Using high resolution quantitative mass spectrometry
  I have explored how immune activation and the metabolic checkpoint kinase
  mTORC1 (mammalian target of rapamycin complex 1) regulate the proteome of
  B lymphocytes to control B cell differentiation. Triggering the B cell re
 ceptor in combination with co-stimulatory signals and cytokines induces co
 nsiderable re-modelling of the B cell protein landscape. I reveal that mTO
 RC1 activity is critical for the expression of transcription factors that 
 regulate B cell differentiation and metabolism\, including aryl hydrocarbo
 n receptor (AHR) and MYC. Inhibiting mTORC1 activity also impairs the expr
 ession of nutrient and amino acid transporters. This work provides a detai
 led map of naïve and immune activated B cell proteomes\, and a resource f
 or exploring and understanding the cellular machinery that direct B cell p
 henotypes.\n\nMy research uses quantitative proteomics and protein biochem
 istry to provide new molecular understanding into how immune cells sense a
 nd respond to their environment and regulate core cellular processes. I co
 mpleted my degree\, PhD and postdoc positions in plant science (in Edinbur
 gh\, California\, Oxford and Dundee)\, but in 2015 I moved fields to use m
 y proteomics background to explore how immune cells respond to stimulation
  and stress. I have an active interest in how immune cell dysfunction is l
 inked to neurodegenerative disease and I’m currently using quantitative 
 mass spectrometry to map immune cells in Parkinson’s and Alzheimer’s d
 isease for biomarker discovery and disease phenotyping. I’ve recently be
 en appointed as a group leader (commencing November 2023) within the Divis
 ion of Cell Signalling and Immunology at the University of Dundee. \n
LOCATION:Kings Hedges Room\, Babraham Research Campus
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