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SUMMARY:Studying human oncoproteins beyond cancer: lessons learned from th
 e RAS GTPases - Dr Pau Castel\; Department of Biochemistry and Molecular P
 harmacology\, NYU School of Medicine
DTSTART:20230703T133000Z
DTEND:20230703T143000Z
UID:TALK200917@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Oncoproteins are well-known drivers of cancer and participate 
 in virtually all steps of oncogenic transformation. Among these\, RAS onco
 proteins are drivers of tumor initiation and progression and therapies tar
 geting these directly or their downstream pathways have resulted in unprec
 edented clinical benefit in cancer. However\, recent advances in genomic m
 edicine have revealed that many of the known RAS oncoproteins and their re
 gulators are also involved in the pathogenesis of a group of congenital di
 sorders termed RASopathies. In these individuals\, germline pathogenic var
 iants give rise to phenotypes that can shed light on the physiological fun
 ction of the proto-oncoprotein. Our laboratory’s research has been focus
 ed on understanding the role of RAS oncoproteins in both cancer and congen
 ital disorders. During my talk I will discuss our recent efforts in charac
 terizing a non-classical RAS GTPase termed RIT1\, which is mutated in both
  cancer and RASopathies. We have identified a novel mechanism of regulatio
 n for this GTPase and have developed unique cellular and animal models to 
 understand the role of RIT1 at the organismal level. Our work provides nov
 el insights into the regulation\, function\, and pathogenesis of RAS oncop
 roteins.   \n\nDr. Pau Castel is an Assistant Professor at the Department 
 of Biochemistry and Molecular Pharmacology at the New York University Scho
 ol of Medicine. Dr. Castel performed his graduate work at Memorial Sloan K
 ettering Cancer Center under the supervision of Dr. José Baselga and unde
 rtook postdoctoral studies at the University of California San Francisco i
 n the laboratory of Dr. Frank McCormick. His research is aimed at understa
 nding the molecular mechanisms underlying oncoprotein transformation in ca
 ncer and congenital disorders\, including RASopathies and the neurofibroma
 toses. His laboratory employs biochemical\, signal transduction\, and mous
 e genetics to study oncoproteins of the Ras-MAPK and PI3K pathways with th
 e goal of developing rational-based therapies for these disorders.    \n
LOCATION:Queen Edith's Room\, Babraham Research Campus
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