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SUMMARY:Population structure and effects of consanguinity on complex disea
 se in British South Asians - Dr Hilary Martin (Human Genetics programme\, 
 Wellcome Sanger Institute)
DTSTART:20230525T123000Z
DTEND:20230525T133000Z
UID:TALK200968@talks.cam.ac.uk
CONTACT:Spencer Keene
DESCRIPTION:Previous genetic and public health research in the Pakistani p
 opulation has focused on the role of consanguinity in increasing recessive
  disease risk\, but little is known about its recent population history\, 
 the effects of endogamy\, or effects of consanguinity on complex disease r
 isk.\n\nI will first describe work we have done elucidating fine-scale pop
 ulation structure\, history and consanguinity patterns using genotype chip
  data from 2\,200 British Pakistanis from the Born in Bradford cohort. I w
 ill then present recent results demonstrating an effect of consanguinity o
 n risk of several common diseases including type 2 diabetes\, PTSD and ast
 hma\, in three large cohorts (Genes & Health\, comprising 50k British Paki
 stanis and Bangladeshis\, UK Biobank\, and 23andMe)\, including a new appr
 oach to deal with confounding.
LOCATION:Heart and Lung Research Institute (ground floor) or Virtually via
  Zoom
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