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SUMMARY:Biomechanics of cancer cells and bacteria using atomic force micro
 scope and modelling - Jinju Chen  (Newcastle University)
DTSTART:20230703T110000Z
DTEND:20230703T113000Z
UID:TALK201166@talks.cam.ac.uk
DESCRIPTION:Cell mechanics of living cells are vital for many cell functio
 ns\, including mechanotransduction\, migration\, and differentiation. It i
 s known that changes in cell mechanics are often correlated with disease p
 rogression. Cell-matrix adhesion is important for the patterning\, integri
 ty and homeostasis of tissues\, and may provide a target for therapy\, for
  example in cancer metastasis. Cell mechanics and the adhesion between cel
 ls and matrix are also important for tissue engineering. Therefore\, it is
  important to study cell mechanics and cell-to-material adhesion.&nbsp\; I
 n this work\, we used the novel fluidics force microscope (FluidFM) to sim
 ultaneously measure cell viscoelasticity and cell-to-surface adhesion forc
 es. A better understanding of the mechanical properties of breast cancer c
 ells is likely also to contribute to the design of improved treatments for
  breast cancer\, which has the second highest incidence of all cancers in 
 women worldwide and is the fourth most common cause of cancer mortality.\n
 On the other hand\, bacteria mechanical properties are important for bacte
 ria to survive in harsh environment (including antibiotics). In this prese
 ntation\, I will also talk about developing a combined computational model
 ling and theoretical modelling to simultaneously determine the bacteria en
 velope stiffness and turgor based on atomic force microscope indentations.
LOCATION:Seminar Room 1\, Newton Institute
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