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SUMMARY:BSU Seminar: 'Modelling the response to vaccine in non-human prima
 tes to define SARS-CoV-2 mechanistic correlates of protection'  - Mélanie
  Prague\, Inria\, University of Bordeaux
DTSTART:20230523T130000Z
DTEND:20230523T140000Z
UID:TALK201307@talks.cam.ac.uk
CONTACT:Alison Quenault
DESCRIPTION:The definition of correlates of protection is critical for the
  development of next generation SARS-CoV-2 vaccine platforms. Here\, we pr
 opose a model-based approach for identifying mechanistic correlates of pro
 tection based on mathematical modelling of viral dynamics and data mining 
 of immunological markers. The application to three different studies in no
 n-human primates evaluating SARS-CoV-2 vaccines based on CD40-targeting\, 
 two-component spike nanoparticle and mRNA 1273 identifies and quantifies t
 wo main mechanisms that are a decrease of rate of cell infection and an in
 crease in clearance of infected cells. Inhibition of RBD binding to ACE2 a
 ppears to be a robust mechanistic correlate of protection across the three
  vaccine platforms although not capturing the whole biological vaccine eff
 ect. The model shows that RBD/ACE2 binding inhibition represents a strong 
 mechanism of protection which required significant reduction in blocking p
 otency to effectively compromise the control of viral replication.\n\nBase
 d on elife paper  https://doi.org/10.7554/eLife.75427\n
LOCATION:Online Seminar
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