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SUMMARY:The interplay of tissue architecture and cell signaling to coordin
 ate collective cell migration dynamics - Michelle Starz-Gaiano (University
  of Maryland\, Baltimore County)
DTSTART:20230810T101500Z
DTEND:20230810T111500Z
UID:TALK201469@talks.cam.ac.uk
DESCRIPTION:Accurate and on-time cell migration is required for animals to
  develop normally and for various functions in adults\, such as wound heal
 ing and immune response. Motile cells use intrinsic genetic information to
  interpret external cues\, which include physical pathways and chemical si
 gnals that guide directional movements and provide temporal information. T
 he responses to this information are highly conserved between many cell ty
 pes and have been well studied. However\, we do not understand how the phy
 sical structures of developing tissues- which are highly dynamic and heter
 ogenous - impact signaling and cell movement. A cluster of cells called bo
 rder cells\, which arise in the developing Drosophila (fruit fly) ovary\, 
 provide an excellent platform for investigating how cell migration is cont
 rolled. Through a combination of in vivo imaging\, genetic analysis\, and 
 mathematical modeling\, we and others have identified the minimal signalin
 g networks controlling a switch from non-motile to motile cell identity\, 
 the critical forces that capture the cell cluster behaviors\, and the phys
 ical constraints that affect cluster shape and motility. Currently\, we ar
 e exploring the impact of tissue architecture on diffusible signal distrib
 ution\, which appears to influence both motile cell specification and dire
 ctional movement\, and we aim to identify emergent properties that apply t
 o motile cell clusters in other contexts.&nbsp\;
LOCATION:Seminar Room 1\, Newton Institute
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