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SUMMARY:Mechanical brain: The force of dendritic spine synapses for memory
  and cognition - Professor Haruo Kasai at The University of Tokyo
DTSTART:20230602T130000Z
DTEND:20230602T143000Z
UID:TALK201565@talks.cam.ac.uk
CONTACT:Ingo Greger
DESCRIPTION:We have used two-photon glutamate uncaging in vitro and in viv
 o to study the functions of dendritic spines in the hippocampus\, cortex\,
  and striatum. We have found the structure-function relationship\, long-te
 rm structural plasticity\, and time-sensitive modulation of this process b
 y dopamine. We recently found that this spine enlargement pushes the presy
 naptic terminal and facilitates the presynaptic functions with muscle-like
  force: mechanical synaptic transmission. Our findings suggest that the br
 ain is mechanical and uses force to leave structural traces for both short
 -term and long-term memory for cognitive functions.\n\nReferences:\n\n1. K
 asai\, H.\, Ucar\, H.\, Morimoto\, Y.\, Eto\, F. & Okazaki\, H. Mechanical
  transmission at spine synapses: Short-term potentiation and working memor
 y. Curr Opin Neurobiol 80\, doi:10.1016/j.conb.2023.102706 (2023).\n\n2. U
 car\, H.\, Watanabe\, S.\, Noguchi\, J.\, Morimoto\, Y.\, Iino\, Y.\, Yagi
 shita\, S.\, Takahashi\, N. & Kasai\, H. Mechanical actions of dendritic-s
 pine enlargement on presynaptic exocytosis. Nature 600\, 686-689\, doi:10.
 1038/s41586-021-04125-7 (2021).\n\n3. Iino\, Y.\, Sawada\, T.\, Yamaguchi\
 , K.\, Tajiri\, M.\, Ishii\, S.\, Kasai\, H. & Yagishita\, S. Dopamine D2 
 receptors in discrimination learning and spine enlargement. Nature 579\, 5
 55-560\, doi:10.1038/s41586-020-2115-1 (2020).\n\n\n\nHost: Ingo Greger at
  LMB
LOCATION:Sanger Seminar Room\, Level 3\, MRC Laboratory of Molecular Biolo
 gy
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