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SUMMARY: Multiscale synthesis of coupled dynamic gene expression during ne
 ural development - Professor Nancy Papolopulu\, School of Medical Sciences
 \, University of Manchester 
DTSTART:20231123T130000Z
DTEND:20231123T140000Z
UID:TALK202183@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:In recent years\, our understanding of how cells transition fr
 om proliferation to differentiation has been transformed by the applicatio
 n of single cell quantitative approaches and live imaging. Such approaches
  have led to by discovery of short-time scale protein expression oscillati
 ons which are exemplified by the expression of HES/Her transcription facto
 rs in neural progenitors. In my talk\, I show how dynamic single cell live
  imaging of knocked-in reporters can be combined with mathematical modelli
 ng to analyse ultradian oscillations during vertebrate neural development\
 , taking into consideration heterogeneity and stochasticity. I will show h
 ow single cell oscillations undergo multiscale synthesis when cells intera
 ct in a tissue environment and how the emergent pattern may control the ra
 te and spacing of differentiation. 
LOCATION:Biffen Lecture theatre and Zoom
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