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SUMMARY:Competition for phospholipids drives astrocyte morphogenesis in th
 e CNS - Professor Marc Freeman from The Vollum Institute\, Oregon Health &
 amp\; Science University\, USA
DTSTART:20240509T140000Z
DTEND:20240509T150000Z
UID:TALK202195@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Astrocytes play crucial roles in regulating neural circuit fun
 ction by forming a dense network of synapse-associated membrane specializa
 tions\, but signaling pathways regulating astrocyte morphogenesis remain p
 oorly defined. We found the Drosophila lipid-binding G protein-coupled rec
 eptor (GPCR) Tre1 is required for astrocytes to establish their intricate 
 morphology in vivo. The lipid phosphate phosphatases Wunen/Wunen2 also reg
 ulate astrocyte morphology and\, via Tre1\, mediate astrocyte-astrocyte co
 mpetition for growth-promoting lipids. Loss of s1pr1\, the functional anal
 og of Tre1 in zebrafish\, disrupts astrocyte process elaboration\, and liv
 e imaging and pharmacology demonstrate that S1pr1 balances proper astrocyt
 e process extension/retraction dynamics during growth. Loss of Tre1 in fli
 es or S1pr1 in zebrafish results in defects in simple assays of motor beha
 vior. Tre1 and S1pr1 are thus potent evolutionarily conserved regulators o
 f the elaboration of astrocyte morphological complexity and\, ultimately\,
  astrocyte control of behavior.
LOCATION:Zoom meeting
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