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SUMMARY:Building patterning-dependent chromatin states during development.
  - Professor Shelby Blythe from Department of Molecular Biosciences\, Nort
 hwestern University\, USA  
DTSTART:20240229T150000Z
DTEND:20240229T160000Z
UID:TALK202201@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:In this seminar\, I will discuss my lab's work on how chromati
 n structure constrains the gene regulatory networks that pattern the embry
 o\, and how changes to chromatin structure are encoded within these develo
 pmental repertoires. By measuring changes to chromatin accessibility patte
 rns in early Drosophila embryos\, we find that accessibility states change
  on a timescale of minutes\, and are influenced not only by cell cycle pro
 gression but also signaling inputs for cell fate specification. What this 
 means is that the complete cis-regulatory landscape for certain developmen
 tal routines such as embryonic segmentation are established gradually\, in
  a step-wise manner dependent on passage through prior regulatory states. 
 Encoded within these regulatory networks are specialized transcription fac
 tors known as Pioneers that\, once activated\, modulate accessibility patt
 erns to accommodate later steps in the process. Importantly\, altering the
  temporal order of these changes disrupts the fidelity of segmentation\, s
 upporting the idea that the temporal sequence of chromatin accessibility s
 tates plays a deterministic role in the developmental program. \n\nThis wo
 rk has led us to investigate how transcription factors contend with bindin
 g DNA in the chromatin context. I will also present unpublished empirical 
 and modeling work to address how competition with nucleosomal substrates l
 ikely sets concentration thresholds critical for the function of the Bicoi
 d morphogen gradient. 
LOCATION:Zoom meeting
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