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SUMMARY:Tracing cell fate specification and pattern formation during branc
 hing morphogenesis - Dr. Lemonia Chatzeli &amp\; Prof. Ignacio Bordeu
DTSTART:20230607T150000Z
DTEND:20230607T160000Z
UID:TALK202264@talks.cam.ac.uk
CONTACT:Dr. Adrien Hallou
DESCRIPTION:Branching morphogenesis is a process whereby flat epithelial s
 heets develop\ninto tree like tissues. This process is driven by tip-local
 ised progenitors that need to balance cell proliferation with differentiat
 ion and epithelial patterning\, but how epithelial progenitors coordinate 
 their output and how these cellular dynamics translate into the large-scal
 e architecture of branched epithelia?. In this talk\, we will discuss a mu
 lti scale approach to answer these questions. Using the murine salivary gl
 ands as a model system and a combination of clonal linage tracing\, single
 -cell analysis and 3d reconstructions\, we will show that progenitors form
  a heterogeneous population that organises in a lineage hierarchy regulate
 d by Notch and KRAS signalling. Moreover\, we will show how that the large
 -scale organisation of the branching epithelium is consistent with a proba
 bilistic model of tip-branching and delay\, which is driven by the persist
 ent expansion of the ductal network and surrounding tissue.
LOCATION:Webinar
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