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SUMMARY:Discrete mechanics of spatially disordered multicellular tissues -
  Oliver Jensen (University of Manchester)
DTSTART:20230804T101500Z
DTEND:20230804T111500Z
UID:TALK202471@talks.cam.ac.uk
DESCRIPTION:Biological tissues typically lack the regular spatial organisa
 tion or homogeneity of engineered materials. To understand the impact of t
 he inherent granularity and stochastic heterogeneity of multicellular tiss
 ues on their macroscopic mechanical properties\, it can be fruitful to res
 ort to discrete models that capture key physical features of individual ti
 ssue components. One popular approach in developmental biology is the vert
 ex model\, which assigns a mechanical energy to individual cells and predi
 cts distributions of stress across growing tissues\, capturing certain fea
 tures that risk being &ldquo\;washed away&rdquo\; using traditional homoge
 nisation approaches\, while exploiting geometric features that are readily
  measured experimentally. Complementing numerical simulations\, discrete c
 alculus methods provide a powerful set of tools with which to analyse the 
 vertex model. I will show how this approach has revealed features such as 
 couple stresses at tricellular junctions in spatially disordered cellular 
 monolayers.
LOCATION:Seminar Room 1\, Newton Institute
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