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SUMMARY:Targeting RNA biology in colorectal cancer - John Knight\, Univers
 ity of Manchester
DTSTART:20230706T100000Z
DTEND:20230706T110000Z
UID:TALK202660@talks.cam.ac.uk
CONTACT:Michael Boemo
DESCRIPTION:Advanced colorectal cancers are treated with first line chemot
 herapy combinations that have broad molecular effects within tumour and no
 n-tumour cells. Despite a huge reliance on these therapies for colorectal 
 and other cancers we do not fully understand how they work at the molecula
 r level. Recent advances have highlighted a forgotten role for these compo
 unds in RNA biology that needs revisiting. Consistent with RNA being an ac
 tionable vulnerability in colorectal cancer I have demonstrated multiple m
 eans to target RNA in preclinical models of the disease. Building on this\
 , my group have developed innovative methods to define how current chemoth
 erapies affect RNA biology in exquisite detail. With this knowledge we hop
 e to identify what determines drug response in disease and design replacem
 ent targeted therapies drawing on advances in RNA-based pharmaceuticals.\n
 \n
LOCATION:Seminar Room\, Department of Pathology\, Tennis Court Road
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