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SUMMARY:Calibrate Weak Intermolecular Ligand Interactions on Nanoparticles
  via the Dynamic Volume of Chain Segments - Prof. Xueqian Kong\, Institute
  of Translational Medicine\, Shanghai Jiao Tong University 
DTSTART:20230720T130000Z
DTEND:20230720T140000Z
UID:TALK202705@talks.cam.ac.uk
CONTACT:Sharon Connor
DESCRIPTION:The surface layer of organic ligands on nanoparticles plays a 
 crucial role to stabilize the core structures\, to control the shapes and 
 morphology\, and to modulate the surface chemistry. The functionalities of
  organic ligands rely not only on their coordination bonds\, but also on t
 he non-coordinating hydrocarbon tails. However\, the interaction of tails 
 involves weak intermolecular forces which are largely intractable on the s
 pectra of common characterization techniques. Here\, we present a solid-st
 ate nuclear magnetic resonance (SSNMR) measurement and modeling strategy t
 o quantify the “dynamic volume” of chain segments. The dynamic volume 
 depicts the accessible space of a chain segment under the confinement of n
 eighboring molecules\, and is inversely proportional to the intermolecular
  dispersive interaction energy. We show that the calculated ligand-ligand 
 interaction energy determines the solution dispersity and melting transiti
 ons of nanoparticles. This dynamic volume concept can be extended beyond e
 xperimental measurements and offer semi-empirical predictions of the inter
 action energies of organic ligands. 
LOCATION:Dept of Chemistry\, Wolfson Lecture Theatre 
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