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SUMMARY:Regrow with the flow: Mechanosensation in the regenerating zebrafi
 sh spinal cord - Dr Samuel Crossman\; The Australian Regenerative Medicine
  Institute\, Monash University 
DTSTART:20230911T123000Z
DTEND:20230911T133000Z
UID:TALK203776@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Unlike mammals\, regenerative vertebrates such as zebrafish an
 d salamanders display near-complete recovery from traumatic spinal cord in
 juries. This exquisite capacity for neural repair can be attributed in par
 t to the reactivation of quiescent progenitor cells\, which re-enter the c
 ell cycle upon injury and serve as neural stem cells in order to replace l
 ost and defective tissues. Despite their critical role in regeneration\, s
 urprisingly little is known about the precise molecular identity of these 
 spinal progenitor cells and the signals that govern their proliferation. \
 n\nHere\, I will present our work on a recently identified population of c
 iliated cells in the zebrafish spinal cord that detect mechanical changes 
 in the injury microenvironment and orchestrate proliferation in the regene
 rating spinal cord. We find that spinal cord injuries initiate a local inf
 lammatory response that triggers an increase in cerebrospinal fluid (CSF) 
 circulation. This increase in CSF flow deforms mechanosensitive immotile c
 ilia within the progenitor domain\, resulting in an influx of calcium ions
  that is required for injury-induced proliferation to occur. Our results i
 dentify calcium as a central regulator of neural stem cell activity and hi
 ghlight a previously uncharacterised role for mechanosensitive immotile ci
 lia in the regenerating CNS.\n
LOCATION:\, Babraham Research Campus
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