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SUMMARY:Intercellular adhesion regulates cell competition in epithelia - A
 ndreas Schoenit (Institut Jacques Monod)
DTSTART:20230904T111000Z
DTEND:20230904T113000Z
UID:TALK203800@talks.cam.ac.uk
DESCRIPTION:Cell competition is a tissue surveillance mechanism to elimina
 te unwanted cells and as such is indispensable in development\, infection 
 pathology and tumorigenesis. Although different biochemical mechanisms are
  proposed\, the role of mechanical forces in determining fitness in compet
 ing cells remains unclear. In this talk\, I will present ongoing work show
 ing&nbsp\;that mechanical cell competition is regulated by relative force 
 transmission capabilities between the competing cells\, exclusively favori
 ng cells with stronger intercellular adhesion. Heterogeneities in cell mec
 hanics evoke increased mechanical activity at tissue interfaces. There\, l
 arge stress fluctuations emerge\, which result in upward forces leading to
  cell elimination. Winning cells resist elimination through relatively hig
 her intercellular adhesion. We demonstrate a conserved mechanism in cultur
 e cells and in highly invasive breast tumors\, suggesting broad important 
 implications for maintaining tissue boundaries and cell invasion pathology
 .&nbsp\;
LOCATION:Seminar Room 1\, Newton Institute
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