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SUMMARY:Mechano-chemical active feedback generates convergence extension i
 n epithelial tissue - Aondoyima Ioratim-uba (University of Bristol)
DTSTART:20230907T103000Z
DTEND:20230907T105000Z
UID:TALK203872@talks.cam.ac.uk
DESCRIPTION:Convergence extension\, the simultaneous elongation of tissue 
 along one axis while narrowing along a perpendicular axis\, occurs during 
 embryonic development. It is a fundamental process that contributes to sha
 ping the organism and it happens in many different species and tissue type
 s. I will present a minimal continuum model\, that can be directly linked 
 to the controlling microscopic biochemistry\, which shows spontaneous conv
 ergence extension. It is comprised of a 2D viscoelastic active material wi
 th a mechano-chemical active feedback mechanism coupled to a substrate via
  friction. Robust convergent extension behaviour emerges beyond a critical
  value of the activity parameter and is controlled by the boundary conditi
 ons and the coupling to the substrate. Oscillations and spatial patterns a
 lso emerge in this model when internal dissipation dominates over friction
 \, as well as in the active elastic limit.
LOCATION:Seminar Room 1\, Newton Institute
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