BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Pharmacological inhibition of protein aggregation within liquid co
 ndensates - Michele Vendruscolo (University of Cambridge)
DTSTART:20231009T133000Z
DTEND:20231009T141000Z
UID:TALK204775@talks.cam.ac.uk
DESCRIPTION:Protein misfolding and aggregation are characteristic of a wid
 e range of neurodegenerative diseases. Emerging evidence suggests that pro
 tein aggregation may occur within liquid condensates formed through phase 
 separation. This mechanism of aggregation creates new challenges and oppor
 tunities for drug discovery for protein misfolding diseases\, which are ot
 herwise still largely incurable. I will discuss the possibility of inhibit
 ing the process of condensation-driven aggregation using small molecules. 
 By using a chemical kinetics approach\, I will illustrate an example of a 
 compound that inhibits the primary nucleation step in protein aggregation 
 within condensates. These initial results suggest a possible therapeutic r
 oute for several neurodegenerative disorders.
LOCATION:Seminar Room 1\, Newton Institute
END:VEVENT
END:VCALENDAR